Detalhe da pesquisa
1.
Ligand-Based Competition Binding by Real-Time 19F NMR in Human Cells.
J Med Chem
; 67(2): 1115-1126, 2024 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38215028
2.
4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.
J Med Chem
; 51(2): 196-218, 2008 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18020435
3.
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.
Mol Cancer Ther
; 6(4): 1198-211, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17431102
4.
Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.
J Med Chem
; 60(6): 2271-2286, 2017 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28199108
5.
Targeting Hsp90 for the treatment of cancer.
Curr Opin Drug Discov Devel
; 9(4): 483-95, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16889231
6.
Discovery and development of pyrazole-scaffold Hsp90 inhibitors.
Curr Top Med Chem
; 6(11): 1193-203, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16842156
7.
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.
J Med Chem
; 48(13): 4212-5, 2005 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15974572
8.
Off-rate screening (ORS) by surface plasmon resonance. An efficient method to kinetically sample hit to lead chemical space from unpurified reaction products.
J Med Chem
; 57(7): 2845-50, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24520903
9.
Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800.
Mol Cancer Ther
; 9(4): 906-19, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20371713
10.
Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone.
J Med Chem
; 52(15): 4794-809, 2009 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19610616
11.
Medicinal chemistry of Hsp90 inhibitors.
Curr Top Med Chem
; 8(10): 859-68, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18673171
12.
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.
Cancer Res
; 68(8): 2850-60, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18413753
13.
3-(5-Chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone.
Bioorg Med Chem Lett
; 15(23): 5197-201, 2005 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16213716